Eastern quolls have a tapering snout, short legs, and erect ears. They can be distinguished from all other species of quoll by the presence of only four toes, rather than five, on the hind feet, lacking the hallux (big toe). They have a thick coat covered by white spots, that can be either light fawn or near black, with off-white underparts stretching from the chin to the underside of the tail.
Eastern quolls are generally about the size of a small domestic cat, with adult males measuring 53 to 66 cm in total length, and having an average weight of 1.1 kg. Females are significantly smaller, measuring 48 to 58 cm and weighing around 0.7 kg.
Quolls are mostly carnivorous. They primarily eat insects, birds, frogs, lizards and fruit.
Eastern quolls inhabit rainforest, heathland, alpine areas, and scrub below 1,500 m. However, they prefer dry grassland and forest mosaics, bounded by agricultural land, particularly where pasture grubs are common.